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E3 ubiquitin-protein ligase rififylin

FUNCTION: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates. more...

PATHWAY: Protein modification; protein ubiquitination.

SUBUNIT: Binds CASP8 and CASP10.

SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein.

ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WZ73-1; Sequence=Displayed; Name=2; IsoId=Q8WZ73-2; Sequence=VSP_015752; Name=3; IsoId=Q8WZ73-3; Sequence=VSP_015751, VSP_015752;

TISSUE SPECIFICITY: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

PTM: Rapidly degraded after stimulation with TNFSF10, probably by caspases.

PTM: Auto-ubiquitinated (in vitro) (By similarity).

PTM: Palmitoylated (By similarity).

SIMILARITY: Contains 1 FYVE-type zinc finger.

SIMILARITY: Contains 1 RING-type zinc finger.

SIMILARITY: Contains 2 SAP domains.


COPYRIGHT: Protein annotation is derived from the UniProt Consortium ( Distributed under the Creative Commons Attribution-NoDerivs License.



  • Homo sapiens

Gene Symbol:

  • RFFL


  • RING finger protein 189
  • RING finger and FYVE-like domain-containing protein 1
  • RING finger protein 34-like
  • Fring
  • FYVE-RING finger protein Sakura
  • CARP-2
  • Caspase regulator CARP2
  • 6.3.2.-
  • Caspases-8 and -10-associated RING finger protein 2

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