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Protein: UB2J2_HUMAN

Ubiquitin-conjugating enzyme E2 J2

FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. more...

PATHWAY: Protein modification; protein ubiquitination.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity).

ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N2K1-1; Sequence=Displayed; Name=2; IsoId=Q8N2K1-2; Sequence=VSP_011572; Note=No experimental confirmation available;

SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.

GENE SYNONYMS: NCUBE2.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • UBE2J2

Synonyms:

  • 6.3.2.19
  • NCUBE-2
  • Non-canonical ubiquitin-conjugating enzyme 2

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