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Protein: POGZ_MOUSE

Pogo transposable element with ZNF domain

FUNCTION: Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (By similarity). more...

SUBUNIT: Interacts with CBX1, CBX3, MAD2L2 and ZNF828. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1 (By similarity).

SUBCELLULAR LOCATION: Nucleus (By similarity). Chromosome (By similarity). Cytoplasm (By similarity). Note=Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3) (By similarity).

SIMILARITY: Contains 9 C2H2-type zinc fingers.

SIMILARITY: Contains 1 DDE domain.

SIMILARITY: Contains 1 HTH CENPB-type DNA-binding domain.

GENE SYNONYMS: Kiaa0461.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Pogz

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