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Protein: NLGN3_MOUSE

Neuroligin-3

FUNCTION: Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia- glia or glia-neuron interactions in the developing peripheral nervous system. more...

SUBUNIT: Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta, and probably through its C-terminus with DLG4/PSD-95 third PDZ domain (By similarity).

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).

TISSUE SPECIFICITY: Brain and arteries (at protein level). Expressed in olfactory bulb and olfactory epithelium. Found in olfactory ensheathing glia but not in olfactory neurons, and in developing peripheral glia. DEVELOPMENTAL STAGE: Detected at embryonic day E17 and postnatal day P1 in retinal astrocytes, spinal chord astrocytes and Schwann cells of the dorsal root ganglion.

SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

No pathway or interaction information available for this record.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Nlgn3

Synonyms:

  • Gliotactin homolog

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