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Protein: MARK2_HUMAN

Serine/threonine-protein kinase MARK2

FUNCTION: Serine/threonine-protein kinase involved in cell polarity and epithelial morphogenesis. Phosphorylates MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may. play a role in graft rejection. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. more...

ENZYME REGULATION: Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212.

SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Note=Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.

ALTERNATIVE PRODUCTS: Event=Alternative promoter usage, Alternative splicing; Named isoforms=14; Name=1; IsoId=Q7KZI7-1; Sequence=Displayed; Note=Produced by alternative promoter usage. No experimental confirmation available; Name=2; IsoId=Q7KZI7-2; Sequence=VSP_051705, VSP_051706; Note=Produced by alternative splicing of isoform 6; Name=3; IsoId=Q7KZI7-3; Sequence=VSP_051705, VSP_051707; Note=Produced by alternative splicing of isoform 6; Name=4; Synonyms=Par-1Balpha; IsoId=Q7KZI7-4; Sequence=VSP_051706, VSP_051707; Note=Produced by alternative splicing of isoform 1; Name=5; IsoId=Q7KZI7-5; Sequence=VSP_051706, VSP_051708; Note=Produced by alternative splicing of isoform 1; Name=6; IsoId=Q7KZI7-6; Sequence=VSP_051705; Note=Produced by alternative promoter usage. No experimental confirmation available; Name=7; IsoId=Q7KZI7-7; Sequence=VSP_051705, VSP_051706, VSP_051707; Note=Produced by alternative splicing of isoform 6. No experimental confirmation available; Name=8; IsoId=Q7KZI7-8; Sequence=VSP_051707; Note=Produced by alternative splicing of isoform 1. No experimental confirmation available; Name=9; IsoId=Q7KZI7-9; Sequence=VSP_051706; Note=Produced by alternative splicing of isoform 1. No experimental confirmation available; Name=10; IsoId=Q7KZI7-10; Sequence=VSP_051705, VSP_051706, VSP_051708; Note=Produced by alternative splicing of isoform 6. No experimental confirmation available; Name=11; IsoId=Q7KZI7-11; Sequence=VSP_051708; Note=Produced by alternative splicing of isoform 1. No experimental confirmation available; Name=12; IsoId=Q7KZI7-12; Sequence=VSP_051705, VSP_051708; Note=Produced by alternative splicing of isoform 6. No experimental confirmation available; Name=13; IsoId=Q7KZI7-13; Sequence=VSP_051705, VSP_039872, VSP_051706, VSP_051707; Note=Produced by alternative splicing of isoform 6; Name=14; IsoId=Q7KZI7-14; Sequence=VSP_051705, VSP_039872, VSP_051707; Note=Produced by alternative splicing of isoform 6;

TISSUE SPECIFICITY: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.

PTM: Autophosphorylated. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser- 212 inhibits the kinase activity (By similarity). Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter- alpha (STRADA) pseudo kinase and CAB39.

SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.

SIMILARITY: Contains 1 KA1 (kinase-associated) domain.

SIMILARITY: Contains 1 protein kinase domain.

SIMILARITY: Contains 1 UBA domain.

SEQUENCE CAUTION: Sequence=AAK82368.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

GENE SYNONYMS: EMK1.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • MARK2

Synonyms:

  • EMK-1
  • PAR1 homolog
  • 2.7.11.1
  • MAP/microtubule affinity-regulating kinase 2
  • ELKL motif kinase 1

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