This version of Pathway Commons has not been updated since October 2011. Please use the new version that is regularly updated.
Send us your feedback.  Sign up for Pathway Commons announcements.  RSS Logo RSS Feed

Protein: ZBT7B_MOUSE

Zinc finger and BTB domain-containing protein 7B

FUNCTION: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes. more...

SUBCELLULAR LOCATION: Nucleus.

TISSUE SPECIFICITY: Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells). DEVELOPMENTAL STAGE: Expressed, beginning at 9.5 days of gestation and at 10.5 days in regions destined to become skin. In adult animals, expression is predominantly in skin.

DISEASE: Note=Defects in Zbtb7b are the cause of helper deficient disease (HD). HD mice are distinguished by the virtual absence of peripheral T-cells of the CD4(+)CD8(-) major histocompatibility complex (MHC) class II-restricted T-helper subset due to a specific block in thymic development. The developmental defect is selective for CD4(+)CD8(-) cells; the maturation of CD4(-)CD8(+) and gamma delta T-cells is normal indicating that lineage commitment is specifically perturbed without affecting positive selection.

SIMILARITY: Contains 1 BTB (POZ) domain.

SIMILARITY: Contains 4 C2H2-type zinc fingers.

SEQUENCE CAUTION: Sequence=AAA61956.1; Type=Frameshift; Positions=96, 328, 336; Sequence=AAA61956.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=CAA85307.1; Type=Frameshift; Positions=96, 328, 336; Sequence=CAA85307.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;

GENE SYNONYMS: Thpok Zfp67.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Zbtb7b

Synonyms:

  • Zinc finger protein Th-POK
  • T-helper-inducing POZ/Krueppel-like factor
  • Zinc finger protein 67
  • c-Krox
  • Krueppel-related zinc finger protein cKrox
  • Zfp-67

Neighborhood Map:

  Loading...

Cytoscape:

 View in Cytoscape

Stable Link:

  • Link to this page
    Link to this page
    Paste link in email or IM:
    Paste HTML to embed in website:
Filter by Data Source:
  • All Data Sources
Filter by Organism:
  • All Organisms

[Update Filter Settings]