Zinc finger and BTB domain-containing protein 7B
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells). DEVELOPMENTAL STAGE: Expressed, beginning at 9.5 days of gestation and at 10.5 days in regions destined to become skin. In adult animals, expression is predominantly in skin.
DISEASE: Note=Defects in Zbtb7b are the cause of helper deficient disease (HD). HD mice are distinguished by the virtual absence of peripheral T-cells of the CD4(+)CD8(-) major histocompatibility complex (MHC) class II-restricted T-helper subset due to a specific block in thymic development. The developmental defect is selective for CD4(+)CD8(-) cells; the maturation of CD4(-)CD8(+) and gamma delta T-cells is normal indicating that lineage commitment is specifically perturbed without affecting positive selection.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 4 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAA61956.1; Type=Frameshift; Positions=96, 328, 336; Sequence=AAA61956.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=CAA85307.1; Type=Frameshift; Positions=96, 328, 336; Sequence=CAA85307.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
GENE SYNONYMS: Thpok Zfp67.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.