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Protein: MELK_MOUSE

Maternal embryonic leucine zipper kinase

FUNCTION: Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. more...

SUBUNIT: Interacts with ZNF622 and PPP1R8 (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

TISSUE SPECIFICITY: Expressed in testis, ovary, thymus, spleen and T-cell. DEVELOPMENTAL STAGE: Expressed in the 2-cell-stage embryo, followed by a strong expression at 8-cell-stage.

PTM: Autophosphorylated (By similarity).

SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

SIMILARITY: Contains 1 KA1 (kinase-associated) domain.

SIMILARITY: Contains 1 protein kinase domain.

GENE SYNONYMS: Kiaa0175 Pk38.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Melk

Synonyms:

  • Protein kinase PK38
  • mPK38
  • 2.7.11.1

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