Protein: MELK_MOUSE
Maternal embryonic leucine zipper kinase
SUBUNIT: Interacts with ZNF622 and PPP1R8 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Potential).
TISSUE SPECIFICITY: Expressed in testis, ovary, thymus, spleen and T-cell. DEVELOPMENTAL STAGE: Expressed in the 2-cell-stage embryo, followed by a strong expression at 8-cell-stage.
PTM: Autophosphorylated (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
SIMILARITY: Contains 1 KA1 (kinase-associated) domain.
SIMILARITY: Contains 1 protein kinase domain.
GENE SYNONYMS: Kiaa0175 Pk38.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
Organism:
- Mus musculus
Gene Symbol:
- Melk
Synonyms:
- Protein kinase PK38
- mPK38
- 2.7.11.1
Links:
Stable Link:
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FUNCTION: Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. more...