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Protein: MRE11_MOUSE

Double-strand break repair protein MRE11A

FUNCTION: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity). COFACTOR: Manganese (By similarity). more...

SUBUNIT: Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN. Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo (By similarity).

SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Localizes to discrete nuclear foci after treatment with genotoxic agents (By similarity).

ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=Q61216-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q61216-2; Sequence=VSP_003263;

PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).

SIMILARITY: Belongs to the MRE11/RAD32 family.

GENE SYNONYMS: Mre11.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Mre11a

Synonyms:

  • MRE11 homolog 1
  • MmMRE11A
  • MRE11 homolog A
  • Meiotic recombination 11 homolog 1
  • Meiotic recombination 11 homolog A

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