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Protein: NTRK1_MOUSE

High affinity nerve growth factor receptor

FUNCTION: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway (By similarity). CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. more...

SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with KIDINS220 and NGFR. Can form a ternary complex with NGFR and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Endocytosed to the endosomes upon treatment of cells with NGF (By similarity).

DOMAIN: The transmembrane domain mediates interaction with KIDINS220 (By similarity).

DOMAIN: The extracellular domain mediates interaction with NGFR (By similarity).

PTM: Ligand-mediated auto-phosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent (By similarity).

SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

SIMILARITY: Contains 2 LRR (leucine-rich) repeats.

SIMILARITY: Contains 1 LRRCT domain.

SIMILARITY: Contains 1 protein kinase domain.

SEQUENCE CAUTION: Sequence=BAE28644.1; Type=Erroneous initiation;

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Ntrk1

Synonyms:

  • Neurotrophic tyrosine kinase receptor type 1
  • 2.7.10.1

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