Protein: PTGIS_HUMAN
Prostacyclin synthase
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
SIMILARITY: Belongs to the cytochrome P450 family. WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP8A1 alleles; URL="http://www.cypalleles.ki.se/cyp8a1.htm";
GENE SYNONYMS: CYP8 CYP8A1.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
Organism:
- Homo sapiens
Gene Symbol:
- PTGIS
Synonyms:
- 5.3.99.4
- Prostaglandin I2 synthase
Links:
Stable Link:
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FUNCTION: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). CATALYTIC ACTIVITY: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11- alpha,15-dihydroxyprosta-5,13-dienoate. COFACTOR: Heme group (By similarity). more...