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Protein: YN12A_YEAST

Transposon Ty1-NL2 Gag polyprotein

FUNCTION: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity). more...

SUBUNIT: Homotrimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

ALTERNATIVE PRODUCTS: Event=Ribosomal frameshifting; Named isoforms=2; Comment=The Gag-Pol polyprotein is generated by a +1 ribosomal frameshift. The ratio of Gag:Gag-Pol varies between 20:1 and 5:1 (By similarity); Name=Transposon Ty1-NL2 Gag polyprotein; IsoId=Q12470-1; Sequence=Displayed; Note=Produced by conventional translation; Name=Transposon Ty1-NL2 Gag-Pol polyprotein; IsoId=Q99337-1; Sequence=External; Note=Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YNL054W-A ORF;

INDUCTION: Ty1-NL2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

DOMAIN: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities (By similarity). MISCELLANEOUS: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).

GENE SYNONYMS: YNLWTy1-2 GAG.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Saccharomyces cerevisiae

Gene Symbol:

  • TY1A-NL2

Synonyms:

  • TYA
  • p54
  • Transposon Ty1 protein A
  • Gag-p4
  • Gag-p45
  • CA
  • TY1A
  • Capsid protein
  • p58
  • Gag-p49

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