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Protein: MCL1_MOUSE

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. more...

SUBUNIT: Interacts with BAD, BOK, BIK, BAX, BAK1, and TPT1 (By similarity). Interacts with BBC3, BCL2L11, BFM and PMAIP1.

SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (By similarity). Cytoplasm (By similarity). Mitochondrion (By similarity). Nucleus, nucleoplasm (By similarity). Note=Cytoplasmic, associated with mitochondria.

INDUCTION: Up-regulated by IL3 and CSF2. Up-regulated in murine embryonal carcinoma cells in response to retinoic acid treatment. Levels reach a maximum after 4 hours, are decreased after 8 hours and are back to maximum after 12 hours. Levels are decreased after 24 hours and back to basal levels after 48 hours. Expression remains constant in retinoic acid-treated embryonic stem cells.

PTM: Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment (By similarity).

PTM: Rapidly degraded in the absence of phosphorylation in the PEST region (By similarity).

PTM: Phosphorylated on several Ser and Thr residues (By similarity).

SIMILARITY: Belongs to the Bcl-2 family.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Mcl1

Synonyms:

  • Bcl-2-related protein EAT/mcl1

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