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Protein: KPCB_RAT

Protein kinase C beta type

FUNCTION: Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-564', 'Ser-649' and 'Ser- 657', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain. more...

ENZYME REGULATION: Activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. Specifically inhibited by Enzastaurin (LY317615) (By similarity).

SUBUNIT: Interacts with PDK1. Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR (By similarity).

SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Membrane; Peripheral membrane protein.

ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Beta-I; IsoId=P68403-1, P04410-1; Sequence=Displayed; Name=Beta-II; IsoId=P68403-2, P04410-2; Sequence=VSP_004739;

PTM: Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly, isoform beta-II is autophosphorylated on 'Thr-641' and 'Ser-660', subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i.e. in the N-terminal and hinge regions have no effect on PKC activity.

SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

SIMILARITY: Contains 1 AGC-kinase C-terminal domain.

SIMILARITY: Contains 1 C2 domain.

SIMILARITY: Contains 2 phorbol-ester/DAG-type zinc fingers.

SIMILARITY: Contains 1 protein kinase domain.

GENE SYNONYMS: Pkcb Prkcb1.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Rattus norvegicus

Gene Symbol:

  • Prkcb

Synonyms:

  • 2.7.11.13
  • PKC-beta
  • PKC-B

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