Protein: RIA1_YEAST
Ribosome assembly protein 1
ENZYME REGULATION: GTPase activity is stimulated in the presence of 60S subunits.
SUBCELLULAR LOCATION: Cytoplasm. MISCELLANEOUS: Present with 7770 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the GTP-binding elongation factor family.
GENE SYNONYMS: EFL1.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
Organism:
- Saccharomyces cerevisiae
Gene Symbol:
- RIA1
Synonyms:
- 3.6.5.-
- EF-2-like GTPase
- Elongation factor-like 1
Stable Link:
- Link to this page
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FUNCTION: GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SDO1, may trigger the GTP-dependent release of TIF6 from 60S pre- ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2. CATALYTIC ACTIVITY: GTP + H2O = GDP + phosphate. more...