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Protein: TAF1_HUMAN

Transcription initiation factor TFIID subunit 1

FUNCTION: Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. more...

ENZYME REGULATION: Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1.

SUBUNIT: TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C- terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N- terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts with SV40 Large T antigen.

SUBCELLULAR LOCATION: Nucleus.

ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P21675-1; Sequence=Displayed; Name=2; IsoId=P21675-2; Sequence=VSP_012362; Name=3; IsoId=P21675-3; Sequence=VSP_023318, VSP_023319; Name=4; IsoId=P21675-4; Sequence=VSP_023319;

PTM: Phosphorylated by casein kinase II in vitro.

DISEASE: Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:314250]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.

SIMILARITY: Belongs to the TAF1 family.

SIMILARITY: Contains 2 bromo domains.

SIMILARITY: Contains 1 HMG box DNA-binding domain.

SIMILARITY: Contains 2 protein kinase domains. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/taf1/";

GENE SYNONYMS: BA2R CCG1 CCGS TAF2A.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • TAF1

Synonyms:

  • TAFII250
  • Transcription initiation factor TFIID 250 kDa subunit
  • TBP-associated factor 250 kDa
  • Cell cycle gene 1 protein
  • 2.7.11.1
  • TAF(II)250
  • TAFII-250
  • p250

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