This portal has not been updated since October 2011. Please use the new PC2 web services.
Send us your feedback.  Sign up for Pathway Commons announcements.  RSS Logo RSS Feed

Protein: KPCA_MOUSE

Protein kinase C alpha type

FUNCTION: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4 (By similarity). more...

FUNCTION: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).

SUBUNIT: Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine (By similarity). Interacts with PICK1 (via PDZ domain) (By similarity). Interacts with TRIM41 (By similarity). Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1.

SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus.

DISEASE: Note=Expression of the mutant form UV25 causes malignant transformation of cells.

SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

SIMILARITY: Contains 1 AGC-kinase C-terminal domain.

SIMILARITY: Contains 1 C2 domain.

SIMILARITY: Contains 2 phorbol-ester/DAG-type zinc fingers.

SIMILARITY: Contains 1 protein kinase domain.

GENE SYNONYMS: Pkca.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Prkca

Synonyms:

  • 2.7.11.13
  • PKC-A
  • PKC-alpha

Neighborhood Map:

  Loading...

Stable Link:

  • Link to this page
    Link to this page
    Paste link in email or IM:
    Paste HTML to embed in website:
Filter by Data Source:
  • All Data Sources
Filter by Organism:
  • All Organisms

[Update Filter Settings]