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Protein: ITAM_HUMAN

Integrin alpha-M

FUNCTION: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. more...

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

DISEASE: Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

SIMILARITY: Belongs to the integrin alpha chain family.

SIMILARITY: Contains 7 FG-GAP repeats.

SIMILARITY: Contains 1 VWFA domain.

GENE SYNONYMS: CD11B CR3A.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • ITGAM

Synonyms:

  • Leukocyte adhesion receptor MO1
  • Cell surface glycoprotein MAC-1 subunit alpha
  • Neutrophil adherence receptor
  • CR-3 alpha chain
  • CD11 antigen-like family member B
  • CD11b

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