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Tumor necrosis factor

FUNCTION: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. more...

SUBUNIT: Homotrimer.

SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.

SUBCELLULAR LOCATION: Tumor necrosis factor, soluble form: Secreted.

PTM: The soluble form derives from the membrane form by proteolytic processing.

PTM: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).

SIMILARITY: Belongs to the tumor necrosis factor family.


COPYRIGHT: Protein annotation is derived from the UniProt Consortium ( Distributed under the Creative Commons Attribution-NoDerivs License.



  • Mus musculus

Gene Symbol:

  • Tnf


  • TNF-a
  • TNF-alpha
  • Tumor necrosis factor, soluble form
  • Tumor necrosis factor, membrane form
  • Cachectin
  • Tumor necrosis factor ligand superfamily member 2

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