Protein: TNFA_MOUSE
Tumor necrosis factor
SUBUNIT: Homotrimer.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.
SUBCELLULAR LOCATION: Tumor necrosis factor, soluble form: Secreted.
PTM: The soluble form derives from the membrane form by proteolytic processing.
PTM: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
SIMILARITY: Belongs to the tumor necrosis factor family.
GENE SYNONYMS: Tnfa Tnfsf2.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
Organism:
- Mus musculus
Gene Symbol:
- Tnf
Synonyms:
- TNF-a
- TNF-alpha
- Tumor necrosis factor, soluble form
- Tumor necrosis factor, membrane form
- Cachectin
- Tumor necrosis factor ligand superfamily member 2
Links:
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FUNCTION: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. more...