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Protein: CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

FUNCTION: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. more...

SUBUNIT: Monomer.

SUBCELLULAR LOCATION: Secreted. POLYMORPHISM: Variant Ile-117 may be a risk factor for atopic asthma. PHARMACEUTICAL: Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia.

SIMILARITY: Belongs to the GM-CSF family. WEB RESOURCE: Name=Leukine; Note=Clinical information on Leukine; URL="http://www.leukine.com/hcp/index.html"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/csf2/";

GENE SYNONYMS: GMCSF.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • CSF2

Synonyms:

  • CSF
  • GM-CSF
  • Colony-stimulating factor
  • Molgramostin
  • Sargramostim

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