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Protein: APOC1_HUMAN

Apolipoprotein C-I

FUNCTION: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. more...

SUBCELLULAR LOCATION: Secreted.

TISSUE SPECIFICITY: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma. MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene. Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).

SIMILARITY: Belongs to the apolipoprotein C1 family. WEB RESOURCE: Name=Wikipedia; Note=Apolipoprotein C1 entry; URL="http://en.wikipedia.org/wiki/Apolipoprotein_C1";

GENE SYNONYMS: APOC1B.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • APOC1

Synonyms:

  • ApoC-IB
  • Apo-CIB'
  • Apolipoprotein C1
  • ApoC-IB'
  • Truncated apolipoprotein C-I
  • Apo-CIB

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