This portal has not been updated since October 2011. Please use the new PC2 web services.
Send us your feedback.  Sign up for Pathway Commons announcements.  RSS Logo RSS Feed

Protein: NUAK1_HUMAN

NUAK family SNF1-like kinase 1

FUNCTION: Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. more...

ENZYME REGULATION: Activated by PKB/AKT1 during glucose starvation. Activated by phosphorylation on Thr-211.

ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60285-1; Sequence=Displayed; Name=2; IsoId=O60285-2; Sequence=VSP_014236, VSP_014237; Note=No experimental confirmation available;

TISSUE SPECIFICITY: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver.

PTM: Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.

PTM: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.

SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

SIMILARITY: Contains 1 protein kinase domain.

SEQUENCE CAUTION: Sequence=BAA25463.2; Type=Erroneous initiation;

GENE SYNONYMS: ARK5 KIAA0537.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • NUAK1

Synonyms:

  • AMPK-related protein kinase 5
  • 2.7.11.1

Neighborhood Map:

  Loading...

Stable Link:

  • Link to this page
    Link to this page
    Paste link in email or IM:
    Paste HTML to embed in website:
Filter by Data Source:
  • All Data Sources
Filter by Organism:
  • All Organisms

[Update Filter Settings]