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Protein: ANGP2_MOUSE

Angiopoietin-2

FUNCTION: Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). more...

SUBCELLULAR LOCATION: Secreted.

TISSUE SPECIFICITY: Expressed only at sites of vascular remodeling.

DOMAIN: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor (By similarity).

SIMILARITY: Contains 1 fibrinogen C-terminal domain.

GENE SYNONYMS: Agpt2.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

No pathway or interaction information available for this record.

 

Organism:

  • Mus musculus

Gene Symbol:

  • Angpt2

Synonyms:

  • ANG-2

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