Eukaryotic translation initiation factor 3 subunit F
SUBUNIT: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination- dependent manner.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. MASS SPECTROMETRY: Mass=37554.8; Method=Unknown; Range=1-357; Source=PubMed:17322308; MASS SPECTROMETRY: Mass=37475.6; Mass_error=0.2; Method=MALDI; Range=1-357; Source=PubMed:18599441;
SIMILARITY: Belongs to the eIF-3 subunit F family.
SIMILARITY: Contains 1 MPN (JAB/Mov34) domain.
GENE SYNONYMS: EIF3S5.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.