COMPONENT_OF
The first entity is a component of the second entity, which is a complex. This interaction is transient in the sense that A component_of B and B component_of C implies A component_of C. This interaction is directed.
STATE_CHANGE
The first entity controls a reaction that changes the state of the second entity, e.g. by phosphorylation or other posttranslational modification, or by a change in subcellular location. This interaction is directed.
REACTS_WITH
The entities participate in a conversion as substrates or products. Controllers are not included. This interaction is undirected.
INTERACTS_WITH
The entities participate in an interaction. Controllers are not included. This interaction is undirected.
SEQUENTIAL_CATALYSIS
The entities catalyze two conversions that are connected via a common molecule, e.g. the first entity produces a substrate that is consumed by the second entity. This interaction is directed.