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Pathway: Cytochrome c-mediated apoptotic response

Reviewed: Vaux, D, 0000-00-00 00:00:00 more...

Authored: Matthews, L, 2004-08-06 15:00:00

Upon its release from the mitochondrial intermembrane space, Cytochrome c binds to and causes a conformational change in the cytoplasmic protein Apaf1. This conformational change allows the Cytochrome c:Apaf1 complex to associate with ATP triggering oligomerization of the Apaf1:Cytochrome c:ATP complex. The apoptosome then associates with Procaspase-9 resulting in the formation of the active caspase-9 holoenzyme which functions in cleaving effector caspases.

References:

  • Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochem Biophys Res Commun 319:944-50 [PubMed]
  • The expanding role of mitochondria in apoptosis. Genes Dev 15:2922-33 [PubMed]

 

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  • Homo sapiens

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