Pathway: Cytochrome c-mediated apoptotic response
Authored: Matthews, L, 2004-08-06 15:00:00
Upon its release from the mitochondrial intermembrane space, Cytochrome c binds to and causes a conformational change in the cytoplasmic protein Apaf1. This conformational change allows the Cytochrome c:Apaf1 complex to associate with ATP triggering oligomerization of the Apaf1:Cytochrome c:ATP complex. The apoptosome then associates with Procaspase-9 resulting in the formation of the active caspase-9 holoenzyme which functions in cleaving effector caspases.
References:
- Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochem Biophys Res Commun 319:944-50 [PubMed]
- The expanding role of mitochondria in apoptosis. Genes Dev 15:2922-33 [PubMed]
Data Source:
- Reactome, Release: 38 [20-Sep-11]
Organism:
- Homo sapiens
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Reviewed: Vaux, D, 0000-00-00 00:00:00 more...