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Pathway: SMAC-mediated dissociation of IAP:caspase complexes

Smac/DIABLO regulates IAP function. Residues 56ΓΆΒ?Β?59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to XIAP thus displaces caspase-9 from the XIAP:Caspase complex (reviewed in Salvesen et al., 2002). more...

References:

  • IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3:401-10 [PubMed]

 

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Organism:

  • Homo sapiens

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