Pathway: SMAC-mediated dissociation of IAP:caspase complexes
References:
- IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3:401-10 [PubMed]
Data Source:
- Reactome, Release: 38 [20-Sep-11]
Organism:
- Homo sapiens
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Smac/DIABLO regulates IAP function. Residues 56ΓΆΒ?Β?59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to XIAP thus displaces caspase-9 from the XIAP:Caspase complex (reviewed in Salvesen et al., 2002). more...